A General Approach to Indolizidine Alkaloids From 1-Benzyloxy-5-(p-toluenesulfonamido)-3-alken-2-ols: Synthesis of (+)-Monomorine I

Abstract

A versatile method for the preparation of indolizidine alkaloids from 1-benzyloxy-5-(p-toluenesulfonamido)-3-alken-2-ols as stereodefined key intermediates has been developed. The utility of this approach was demonstrated by the synthesis of (+)-monomorine I.