RELATIONSHIP BETWEEN HUMORAL AND CELLULAR ISOANTIBODIES I. INABILITY OF HUMORAL ISOANTIBODIES TO PREVENT THE CYTOTOXIC EFFECT OF IMMUNE LYMPHOCYTES

Abstract

Interactions between humoral antibodies and immune lymph node cells have been tested both in vivo and in tissue culture. In three tumour-host systems, immune lymph node cells of host strain type suppressed the enhancing effect of antiserum upon incompatible tumours, while antiserum could not prevent the cytotoxic effect of immune lymph node cells. These relationships were observed even when excess amounts of antiserum and minimum active doses of immune lymphocytes were used. In tissue culture, adsorption of immune lymphocytes upon allogeneic macrophages or tumour cells, and the subsequent cytotoxic effect upon target cells, was not inhibited by the previous treatment of the target cells with anti-target cell antiserum.