Intracellular Bacteria in the Peripheral Blood in Staphylococcal Bacteremia

Abstract

Brief Communication1 July 1962Intracellular Bacteria in the Peripheral Blood in Staphylococcal BacteremiaWILLIAM R. MCCABE, M.D., JOSEPH J. LAPORTEWILLIAM R. MCCABE, M.D.Search for more papers by this author, JOSEPH J. LAPORTESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-1-141 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe paramount importance of Staphylococcus aureus as a cause of hospital-acquired infections is well recognized. Despite extensive investigation, the pathogenesis and the nature and importance of host defenses in staphylococcal infections have not been clearly defined. In fact there is experimental evidence that the usually protective mechanism of phagocytosis may actually perpetuate staphylococcal bacteremia (1, 2). Studies of bacteremia in rabbits suggest that although pathogenic staphylococci are readily ingested by phagocytic leukocytes, some continue to reside undamaged in this intracellular location and are provided a protective environment which hinders their destruction by other host defenses (3).This report demonstrates that...References1. ROGERSTOMPSETT DER: The survival of staphylococci within human leukocytes. J. Exp. Med. 95: 209, 1952. CrossrefMedlineGoogle Scholar2. MELLYTHOMISONROGERS MAJBDE: Fate of staphylococci within human leukocytes. J. Exp. Med. 112: 1121, 1960. CrossrefMedlineGoogle Scholar3. ROGERS DE: Studies on bacteremia. I. Mechanisms relating to the persistence of bacteremia in rabbits following the intravenous injection of staphylococci. J. Exp. Med. 103: 713, 1956. CrossrefMedlineGoogle Scholar4. DIGGSSTURNBELL LWDA: The Morphology of Human Blood Cells, W. B. Saunders Company, Philadelphia, 1956, pp. 124, 155, 156. Google Scholar5. HUMPHREY AA: Use of the buffy layer in the rapid diagnosis of septicemia. Amer. J. Clin. Path. 14: 358, 1944. CrossrefGoogle Scholar6. COLE AC: Cerebro-spinal meningitis: meningococci found in peripheral blood films. Lancet 1: 750, 1915. CrossrefGoogle Scholar7. KING WW: Early diagnosis of cerebro-spinal meningitis by the examination of stained blood films. J. A. M. A. 71: 2048, 1918. CrossrefGoogle Scholar8. BUTTER HM: Blood Cultures and Their Significance, J. & A. Churchill Ltd., London, 1937. Google Scholar9. OTTENBERG R: The rate and location of removal of bacteria from the blood in human diseases. Arch. Path. 11: 766, 1931. Google Scholar10. MACNEALFRISBEE WJFC: Bacteriophage as a therapeutic agent in staphylococcus bacteremia. J. A. M. A. 99: 1150, 1932. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisRequests for reprints should be addressed to William R. McCabe, M.D., Veterans Administration Hospital, 820 South Damen Avenue, Chicago 12, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfectious diseases manifested in the peripheral bloodRapid and Definitive Diagnosis of Infectious Diseases Using Peripheral Blood SmearsNonculture techniques using blood specimens for the diagnosis of infectious diseaseEARLY DETECTION OF BACTEREMIA BY PERIPHERAL BLOOD SMEARS IN CRITICALLY ILL NEWBORNSPneumococcal type-associated variability in alternate complement pathway activationNBT Test and InfectionHyposplenism and pneumococcemiaLEUCOCYTES CONTAINING BACTERIA IN PLAIN BLOOD FILMS FROM PATIENTS WITH SEPTICAEMIASpectrum of Acute Diarrhea in a General Hospital 1 July 1962Volume 57, Issue 1Page: 141-143KeywordsBacteremiaBacteriaBloodBlood plasmaIntracellular pathogensPathogenesisPhagocytosisRabbitsStaphylococcal infectionStaphylococcus aureus Issue Published: 1 July 1962 PDF DownloadLoading ...