Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.8K citations

Cent Inhibition, Inhibitory Activity, Biochemistry +8

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Neurological Disorder +7

Molecular characterization of a peripheral receptor for cannabinoids

Sean Munro, Kerrie L. Thomas, Muna Abu-Shaar · Nature · 1993 · 5K citations

Cannabis Use, Molecular Pharmacology, Functional Selectivity +7

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Lisa A. Matsuda, Stephen J. Lolait, Michael Brownstein et al. · Nature · 1990 · 5K citations

Cannabis Use, Molecular Pharmacology, Biochemistry +11

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Liya Qin, Xuefei Wu, Michelle L. Block et al. · Glia · 2007 · 2.1K citations · Full text