p53 Mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui et al. · Nature · 2006 · 3.8K citations

Life Sciences, Neurobiology, Neuroscience +12

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech et al. · The Journal of Cell Biology · 2005 · 3.3K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

John W. Olney · Science · 1969 · 1.8K citations

Life Sciences, Endocrinology, Neuroscience +13

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

Diane Crighton, Simon Wilkinson, Jim O’Prey et al. · Cell · 2006 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

Tianzheng Yu, James L. Robotham, Yisang Yoon · Proceedings of the National Academy of Sciences · 2006 · 1.2K citations · Full text

Life Sciences, Cell Biology, Physiology +17