Impact of CYP3A5*3 and CYP2C8-HapC on Paclitaxel/Carboplatin-Induced Myelosuppression in Patients with Ovarian Cancer

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

Atiqur Rahman, Ken Korzekwa, James Grogan et al. · PubMed · 1994 · 391 citations

Medicine, Biochemistry, Pharmacology +17

Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme.

James W. Harris, Atiqur Rahman, Bok-Ryang Kim et al. · PubMed · 1994 · 286 citations

Medicine, Biochemistry, Pharmacology +17

Pharmacogenetic Assessment of Toxicity and Outcome After Platinum Plus Taxane Chemotherapy in Ovarian Cancer: The Scottish Randomised Trial in Ovarian Cancer

Sharon Marsh, Cristi R. King, Gillian Gifford et al. · Journal of Clinical Oncology · 2007 · 237 citations · Full text

Medicine, Oncology, Pharmacology +17

Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation.

Thierry Cresteil, Bernard Monsarrat, Paul Alvinerie et al. · PubMed · 1994 · 232 citations

Medicine, Biochemistry, Pharmacology +17