Concepedia

Implementation of A Universal Analytical Method in Early-Stage Development of Human Antibody Therapeutics: Application to Pharmacokinetic Assessment For Candidate Selection

Judy Shih, Vimal Patel, Andrew D. Watson, Todd Hager, Peng Luan, Hossein Salimi-Moosavi, Mark Ma

Bioanalysis · 2012 · 17 citations · 8 references

DOI

Abstract

This assay has wide applicability as a default bioanalytical approach in therapeutic candidate selection and preliminary pharmacokinetics evaluation during early-stage therapeutic development.

References

8

Bioconjugate techniques

General Pharmacology The Vascular System · 1997 · 749 citations

Recommendations for the Bioanalytical Method Validation of Ligand-Binding Assays to Support Pharmacokinetic Assessments of Macromolecules

Binodh DeSilva, Wendell C. Smith, Russell Weiner et al. · Pharmaceutical Research · 2003 · 610 citations

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Ligand-Binding Mass Spectrometry to Study Biotransformation of Fusion Protein Drugs and Guide Immunoassay Development: Strategic Approach and Application to Peptibodies Targeting the Thrombopoietin Receptor

Michael Hall, Colin V. Gegg, Kenneth W. Walker et al. · The AAPS Journal · 2010 · 59 citations · Full text

, , +14

Evaluation of a generic immunoassay with drug tolerance to detect immune complexes in serum samples from cynomolgus monkeys after administration of human antibodies

Kay Stubenrauch, Uwe Wessels, Ulrich Essig et al. · Journal of Pharmaceutical and Biomedical Analysis · 2010 · 56 citations

, , +13

Application of The Gyrolab™ Platform to Ligand-Binding Assays: A User’s Perspective

Johanna Mora, Linda Obenauer-Kutner, Vimal Patel · Bioanalysis · 2010 · 54 citations

, , +22