Concepedia

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

Manik C. Ghosh, De‐Liang Zhang, Suh Young Jeong, Gennadiy Kovtunovych, Hayden Ollivierre-Wilson, Audrey Noguchi, Tiffany Tu, Thomas Senecal, Gabrielle Robinson, Daniel R. Crooks,

Cell Metabolism · 2013 · 182 citations · 29 references

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29

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

Xin Yi, Yu Liang, Emilia Huerta‐Sánchez et al. · Science · 2010 · 1.7K citations · Full text

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A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

Daniel G. MacArthur, Suganthi Balasubramanian, Adam Frankish et al. · Science · 2012 · 1.3K citations · Full text

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Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

Abigail W. Bigham, Marc Bauchet, Dalila Pinto et al. · PLoS Genetics · 2010 · 611 citations · Full text

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Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

Timothy LaVaute, Sophia Smith, Sharon Cooperman et al. · Nature Genetics · 2001 · 520 citations

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An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

Ameen A. Salahudeen, Joel W. Thompson, Julio C. Ruiz et al. · Science · 2009 · 434 citations · Full text

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