The Journal of Infectious Diseases · 1986 · 30 citations · 9 references
The cutaneous application of antiviral agents was studied by iontophoresis, a process that increases penetration of most drugs 20- to 60-fold. Twenty-seven subjects with vesicular orolabial herpes were treated one time in a double-blind, placebo-controlled clinical study: nine received vidarabine monophosphate (ara-AMP), nine received acyclovir (ACV), and nine received NaCl. Ara-AMP-treated lesions yielded lower titers of virus after 24 hr compared with lesions treated with NaCl or ACV (P less than .05). Ara-AMP significantly decreased the duration of shedding of virus (P less than .05) and time to dry crust (P less than .05) compared with the other two agents. There was a trend toward decreased healing time after ara-AMP treatment.
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Successful treatment of herpes labialis with topical acyclovir.
A. P. Fiddian, Jane Yeo, R Stubbings et al. · BMJ · 1983 · 124 citations · Full text
Failure of acyclovir cream in treatment of recurrent herpes labialis.
MARCIA SHAW, Melanie King, J. M. Best et al. · BMJ · 1985 · 89 citations · Full text
Therapeutic Effect, Clinical Dermatology, Recurrent Herpes +4