1-<i>tert</i>-Butoxy-2-<i>tert</i>-butoxycarbonyl- 1,2-dihydroisoquinoline: A Novel and Chemoselective <i>tert</i>-Butoxycarbonylation Reagent

Abstract

[reaction: see text] The use of 1-tert-butoxy-2-tert-butoxycarbonyl-1,2-dihydroisoquinoline (BBDI) as tert-butoxycarbonylation reagent for aromatic and aliphatic amine hydrochlorides and phenols in the absence of a base has been demonstrated. The reactions proceed chemoselectively in high yield under mild conditions.