Organic Letters · 2013 · 48 citations · 37 references
PharmacyChemistryChromatographic AnalysisOrganometallic ChemistrySynthetic Medicinal ChemistryChiral SeparationSpectroscopic Analysis Of PharmaceuticalsChiral Analysis By SpectroscopyChiral Derivatization ReagentsEnantiomeric Purity AssessmentEnantiomeric Separation
A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral hydroxylamines by (1)H NMR spectroscopic analysis is described, involving their treatment with 2-formylphenylboronic acid and enantiopure BINOL to afford a mixture of diastereomeric nitrono-boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent hydroxylamine.
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