Concepedia

Single molecule detection in nanofluidic digital array enables accurate measurement of DNA copy number

Somanath Bhat, Jan Herrmann, Paul Armishaw, Philippe Corbisier, Kerry R. Emslie

Analytical and Bioanalytical Chemistry · 2009 · 224 citations · 13 references

Concepts

EngineeringGeneticsMolecular BiologyBiosensorsNanobiotechnologyNanotechnologyDna BiosensorsMicrofluidic BiosensorsMicrofluidicsNucleic Acid BiosensorsSingle-molecule DetectionSingle-molecule MeasurementsDigital Molecular DetectionDna Copy Number EstimationDna NanobiosensorsLow-copy Number Dna AnalysisMicroarray-based Copy Number DetectionNanopore-based Detection

References

13

Modelling Spatial Patterns

B. D. Ripley · Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1977 · 2.5K citations

Computing, Geography, Spatial Analysis +12

<b>spatstat</b>: An<i>R</i>Package for Analyzing Spatial Point Patterns

Adrian Baddeley, Rolf Turner · Journal of Statistical Software · 2005 · 2.4K citations · Full text

Computing, Biostatistics, Spatial Analysis +13

Bert Vogelstein, Kenneth W. Kinzler · Proceedings of the National Academy of Sciences · 1999 · 1.7K citations

Medicine, Genetics, Molecular Biology +17

Digital PCR for the molecular detection of fetal chromosomal aneuploidy

Yuk Ming Dennis Lo, Fiona M. F. Lun, Kelvin Chan et al. · Proceedings of the National Academy of Sciences · 2007 · 434 citations · Full text

Medicine, Genetics, Molecular Genetics +16

Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma

Fiona M. F. Lun, Rossa W. K. Chiu, K.C. Allen Chan et al. · Clinical Chemistry · 2008 · 433 citations · Full text

Medicine, Genetics, Molecular Biology +15