Synthetic Communications · 1988 · 17 citations · 7 references
Natural Product SynthesisEngineeringAntifungal AgentAntifungal AgentsMedicineShort Convergent SynthesisOrganic Chemistry12-Membered MacrolideHigh Antifungal ActivitiesAntimicrobial CompoundChemistryPharmacologySynthetic ChemistryBiomolecular EngineeringConvergent Synthesis
Abstract A short, convergent synthesis of (±) patulolide A, a 12-membered macrolide with high antifungal activities is hereby reported. It has been achieved in 10 steps from 1-bromopentanal and 4-hydroxypent-1-yne.
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