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An Effective Method for the Preparation of ω-Bromoalkanols from α,ω-Diols
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1985
Year
HalogenationDean-stark Water SeparatorEngineeringPure ω-Bromoalkanols 2MedicineEffective MethodDiols 1Organic ChemistryAnalytical ChemistryChemical ContaminantChemistryChromatographyPharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
Pure ω-bromoalkanols 2 (n = 2-12), not contaminated by any dibromoalkanes or unreacted diols 1, were prepared in good yields by refluxing a mixture of diols 1, aqueous (48%) hydrogen bromide, and benzene using a Dean-Stark water separator.