Amyloidosis with an Unusual Bleeding Diathesis

Abstract

Case Studies1 February 1963Amyloidosis with an Unusual Bleeding DiathesisObservations on the Use of Epsilon Amino Caproic AcidPAUL D. REDLEAF, M.D., RICHARD B. DAVIS, M.D., CHESTER KUCINSKI, M.D., LUCILLE HOILUND, M.D., PH.D., HENRY GANS, M.D.PAUL D. REDLEAF, M.D.Search for more papers by this author, RICHARD B. DAVIS, M.D.Search for more papers by this author, CHESTER KUCINSKI, M.D.Search for more papers by this author, LUCILLE HOILUND, M.D., PH.D.Search for more papers by this author, HENRY GANS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-2-347 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemorrhagic manifestations occur frequently in amyloidosis (1, 2). In isolated instances hypoprothrombinemia (3) or hypofibrinogenemia (4) may be responsible for major bleeding difficulties. Usually, however, no specific deficiency of coagulation factors can be demonstrated, and direct involvement of blood vessels with amyloid has been invoked to explain the hemorrhagic tendency.This paper presents a case in which primary amyloidosis was associated with a severe bleeding diathesis and abnormal fibrinolysis, findings of which have not been reported previously. The use of epsilon amino caproic acid (EACA) during bleeding episodes, which was of temporary benefit, and the finding of persistently elevated serum...References1. GOLTZ RW: Systemic amyloidosis. A review of the skin and mucous membrane lesion and a report of two cases. Medicine (Balt.) 31: 381, 1952. CrossrefMedlineGoogle Scholar2. RUKAVINABLOCKJACKSONFALLSCAREYCURTIS JGWDCEHFJHAC: Primary systemic amyloidosis: a review and an experimental, genetic, and clinical study of 29 cases with particular emphasis on the familial form. Medicine (Balt.) 35: 239, 1956. CrossrefMedlineGoogle Scholar3. 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Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Departments of Medicine, Anatomy and Surgery, University of Minnesota Hospitals, Minneapolis 14, Minnesota.Dr. Richard B. Davis is a Special Research Fellow, United States Public Health Service.Requests for reprints should be addressed to Paul D. Redleaf, M.D., 352 Lowry Medical Arts Building, St. Paul 2, Minnesota. 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KASTRUL, M.D.Case 10-1964 1 February 1963Volume 58, Issue 2Page: 347-354KeywordsAmino acidsAmyloidosisCoagulation factorsFibrinolysisHemorrhageHospital medicineMedical servicesPhosphatasesResearch laboratoriesSurgery Issue Published: 1 February 1963 PDF DownloadLoading ...