The effect of low ph and hypoxia on the cytotoxic effects of SR4233 and mitomycin C in vitro

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

Peter Vaupel, Karlheinz Schlenger, Claudia Knoop et al. · PubMed · 1991 · 957 citations

Medicine, Oncology, Breast Oncology +15

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

Beverly A. Teicher, John S. Lazo, Alan C. Sartorelli · PubMed · 1981 · 559 citations

Medicine, Oncology, Pharmacology +8

Intermittent blood flow in a murine tumor: radiobiological effects.

David J. Chaplin, Peggy L. Olive, Ralph E. Durand · PubMed · 1987 · 438 citations

Medicine, Cancer Biology, Oncology +13

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

Elaine M. Zeman, Jeremy Brown, Marilyn J. Lemmon et al. · International Journal of Radiation Oncology*Biology*Physics · 1986 · 395 citations

Life Sciences, Cell Biology, Toxicology +8

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

David Siegel, N W Gibson, Peter C. Preusch et al. · PubMed · 1990 · 225 citations

Medicine, Molecular Biology, Oncology +15