Alendronate affects long bone length and growth plate morphology in the oim mouse model for Osteogenesis Imperfecta

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

Hans-Peter Gerber, Thiennu H. Vu, Anne Ryan et al. · Nature Medicine · 1999 · 2.1K citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +13

Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

Steven P. Luckman, D. E. Hughes, Fraser P. Coxon et al. · Journal of Bone and Mineral Research · 1998 · 1.2K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Cyclic Administration of Pamidronate in Children with Severe Osteogenesis Imperfecta

Francis H. Glorieux, Nicholas Bishop, Horacio Plotkin et al. · New England Journal of Medicine · 1998 · 1K citations · Full text

Medicine, Orthopedic Surgery, Bone Metabolism +15

Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase

James D. Bergstrom, Richard G. Bostedor, P. Masarachia et al. · Archives of Biochemistry and Biophysics · 2000 · 401 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Regulated Production of Mineralization-competent Matrix Vesicles in Hypertrophic Chondrocytes

Thorsten Kirsch, Hyun-Duck Nah, Irving M. Shapiro et al. · The Journal of Cell Biology · 1997 · 267 citations · Full text

Medicine, Cell Biology, Physiology +15