Altered Inter-Subregion Connectivity of the Default Mode Network in Relapsing Remitting Multiple Sclerosis: A Functional and Structural Connectivity Study

Fuqing Zhou, Ying Zhuang, Honghan Gong, Bo Wang, Xing Wang, Qi Chen, Lin Wu, Hui Wan

PLoS ONE · 2014 · 59 citations · 45 references

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Abstract

In the connections of paired DMN subregions, we observed decreased SC and increased FC in RRMS patients. The relationship between MS-related structural abnormalities and clinical markers suggests that the disruption of this long-distance "inter-subregion" connectivity (white matter) may significantly impact the integrity of the network's function.

References

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