Transplantation · 1986 · 82 citations · 0 references
MedicineImmunologyNephrologyKidney TransplantationRenal PathophysiologyTransplant ImmunologyAcute Kidney InjuryImmunosuppression In Kidney TransplantationPlasma ProteinsRenal DiseaseRenal ImmunopathologyRenal ToxicityAcute-phase MediatorsCyclosporine DosingFactor Viii ActivationFactor Viii AlterationsImmune-mediated Vascular InjuryImmunopathology Of Renal DiseaseNephrotoxic InjuryNephrotoxic Kidney Injury
Very high plasma concentrations of factor-VIII-related antigen (RAG) (VIII-RAG) were found in renal allograft recipients during periods of nephrotoxicity induced by cyclosporine. In eight recipients, who were investigated at weekly intervals, levels of factor-VIII-RAG fell toward normal as the dose of cyclosporine was reduced. Plasma levels of C-reactive protein, an acute phase reactant protein, were never raised in these recipients. These findings are further evidence that toxic doses of cyclosporine are associated with vascular injury.