Publication | Closed Access
Oxidation Products of Phenolic Thiocolchicines: Ring a Quinones and Dienones
11
Citations
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References
1998
Year
Bioorganic ChemistryHeterocyclicBiochemistryMedicineNatural SciencesPara-quinone 6Selective DemethylationOrganic ChemistryDiphenol 5Phenolic ThiocolchicinesPhytochemicalHeterocycle ChemistryPhytochemistryPharmacologyRedox BiologySynthetic ChemistryNatural Product Synthesis
Abstract An improved, highly selective demethylation of thiocolchicine (1) to the diphenol 5 is described. Oxidation of 2 to para-quinone 6 and of 4 and 5 to ortho-quinones 8 and 10 is first reported. Also, 2-demethylthiocolchicine (3) was oxidized to the quinone methide 7.
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