Vox Sanguinis · 2001 · 92 citations · 9 references
Life SciencesInfectious DiseasesMicrobiologyInfection PreventionMedical MicrobiologyTransfusion MedicineHealthcare-associated Infection PreventionSterile TechniqueBacterial Contamination PreventionBacterial Infection PreventionBlood Product Infection SafetyDisinfectionDisinfection Efficacy AssessmentDisinfection ValidationPlatingTransfusion-associated Infection Prevention
BACKGROUND AND OBJECTIVE: To validate a standardized optimal national procedure for donor arm disinfection. MATERIALS AND METHODS: A direct swabbing and plating technique was used to enumerate bacteria present on the arm pre- and postdisinfection. Twelve donor arm disinfection techniques were evaluated. RESULTS: The Medi-Flex Adapted method, consisting of a two-stage process with an initial application of isopropyl alcohol followed by tincture of iodine, produced the best arm disinfection. A percentage reduction in bacterial counts of 99.79% (logarithmic reduction of 2.67) was obtained. Postdisinfection, 70% of donors had bacterial counts of zero, and 98% had counts of 10 or less. CONCLUSION: The Medi-Flex disinfection method offers the English National Blood Service a validated, optimal 'best practice' disinfection technique and should contribute significantly to the reduction in risk of transmission of bacteria by transfusion.
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John R. Little, Patrick R. Murray, P Traynor et al. · The American Journal of Medicine · 1999 · 123 citations
Transfusion-related sepsis after prolonged platelet storage
Kenneth C. Anderson, Michael A. Lew, Barbara C. Gorgone et al. · The American Journal of Medicine · 1986 · 110 citations
Fatal <i>Clostridium perfringens</i> sepsis from a pooled platelet transfusion
McDonald, Hartley, Kim Orchard et al. · Transfusion Medicine · 1998 · 99 citations
Medicine, Hematology, Microbiology +17
Evaluation of donor skin disinfection methods
Mindy Goldman, Gilles Roy, N. Fréchette et al. · Transfusion · 1997 · 94 citations
Life Sciences, Microbiology, Allergy +13