The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Natural Sciences, Biophysics, Cell Biology +16

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

Erwin Neher, Joe Henry Steinbach · The Journal of Physiology · 1978 · 849 citations · Full text

Medicine, Pharmacology, Physiology +16

Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor.

Steven M. Sine, Toni Claudio · Journal of Biological Chemistry · 1991 · 167 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Interaction of Muscle Relaxants and Local Anesthetics at the Neuromuscular Junction

Shogo Matsuo, D. B. S. RAO, Imtiaz Chaudry et al. · Anesthesia & Analgesia · 1978 · 90 citations

Medicine, Anesthesiology, Pharmacology +16

Local Anesthetics Noncompetitively Inhibit Function of Four Distinct Nicotinic Acetylcholine Receptor Subtypes

Cynthia L. Gentry, Ronald J. Lukas · Journal of Pharmacology and Experimental Therapeutics · 2001 · 58 citations

Medicine, Neuroscience, Pharmacology +17