Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase

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Hematological Malignancy, Hematology, Immunology +5

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Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

Guang‐Biao Zhou, Hui Kang, Lan Wang et al. · Blood · 2006 · 197 citations · Full text

Oridonin, a diterpenoid purified from<i>Rabdosia rubescens</i>, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways

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Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

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