Diagnostic criteria and adjudication process both determine published event-rates: The ACTION trial experience

Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)

Morris J. Brown, Christopher R. Palmer, A Castaigne et al. · The Lancet · 2000 · 1.2K citations

Non-pharmacological Intervention, Hypertension, Urology +10

Randomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study

Lennart Hansson, Thomas Hedner, Per Lund‐Johansen et al. · The Lancet · 2000 · 900 citations

Hypertension, Cardiovascular Disease, Medicine +8

Prospective Randomized Open Blinded End-point (PROBE) Study. A novel design for intervention trials

Lennart Hansson, Thomas Hedner, Björn Dahlöf · Blood Pressure · 1992 · 566 citations

Clinical Endpoint, Surgery, A Novel Design +18

Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial

Philip A. Poole‐Wilson, Jacobus Lubsen, Bridget‐Anne Kirwan et al. · The Lancet · 2004 · 515 citations

Thrombosis, Non-pharmacological Intervention, Action Trial +11

Systematic adjudication of myocardial infarction end-points in an international clinical trial

Kenneth W. Mahaffey, Robert A. Harrington, K. Martijn Akkerhuis et al. · Trials · 2001 · 74 citations · Full text

Thrombosis, Heart Failure, Cardiovascular Disease +13