TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

Matthias Grell, Eleni Douni, Harald Wajant et al. · Cell · 1995 · 1.3K citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Induction of apoptosis in mature T cells by tumour necrosis factor

Lixin Zheng, Galen H. Fisher, Robert E. Miller et al. · Nature · 1995 · 1.1K citations

Life Sciences, Cell Biology, Immunology +14

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

Jacques J. Peschon, Dauphine Torrance, Kim L. Stocking et al. · The Journal of Immunology · 1998 · 708 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

Sharon Erickson, Frédéric J. de Sauvage, Kristine Kikly et al. · Nature · 1994 · 599 citations

Life Sciences, Immunology, Oncology +10

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

Louis A. Tartaglia, Diane Pennica, David V. Goeddel · Journal of Biological Chemistry · 1993 · 567 citations · Full text

Life Sciences, Cell Biology, Immunology +16