Concepedia

Platinum(ii) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity

Zuqin Xue, Miaoxin Lin, Jianhui Zhu, Junfeng Zhang, Yi‐Zhi Li, Zijian Guo

Chemical Communications · 2010 · 71 citations · 15 references

DOI

Concepts

Abstract

Platinum(II) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin.

References

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