R.G.G. Russell

Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras

Steven P. Luckman, D. E. Hughes, Fraser P. Coxon et al. · Journal of Bone and Mineral Research · 1998 · 1.2K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

An interleukin 1 like factor stimulates bone resorption in vitro

Maxine Gowen, David D. Wood, Earl J. Ihrie et al. · Nature · 1983 · 1K citations

Medicine, Immunology, Bone Metabolism +11

Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite

George H. Nancollas, Ruikang Tang, Roger Phipps et al. · Bone · 2005 · 859 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +12

Diphosphonates Inhibit Hydroxyapatite Dissolution in vitro and Bone Resorption in Tissue Culture and in vivo

H. Fleisch, R. Graham, R.G.G. Russell et al. · Science · 1969 · 759 citations

Medicine, Endocrinology, Pharmacology +15

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation <i>in vitro</i>

John Fisher, Michael J. Rogers, J. M. Halasy et al. · Proceedings of the National Academy of Sciences · 1999 · 679 citations

Medicine, Biochemistry, Pharmacology +17