B islet cells of pancreas are the site of expression of the human insulin gene in transgenic mice

Methods in Enzymology , Vol

S P Colowick, M D Joshi, Jagannathan et al. · 1966 · 26.2K citations

Biosynthesis, Engineering, Cellular Enzymology +5

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

John M. Chirgwin, Alan Przybyla, Raymond J. MacDonald et al. · Biochemistry · 1979 · 22.2K citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

Douglas Hanahan · Nature · 1985 · 1.3K citations

Pancreatic Cancer, Transgenic Mouse Models, Pancreatic β-Cell Tumours +8

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

Michael Walker, Philip J. Barr, William J. Rutter · Science · 1985 · 701 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

Michael Walker, Anne M. Boulet, William J. Rutter · Nature · 1983 · 659 citations

Developmental Biology, Signal Transduction, Signaling Pathway +13