Concepedia

Age-Related Macular Degeneration Is Associated with the HLA-Cw*0701 Genotype and the Natural Killer Cell Receptor AA Haplotype

Srinivas Goverdhan, Salim I. Khakoo, Hannah Gaston, Xiaoli Chen, Andrew Lotery

Investigative Ophthalmology & Visual Science · 2008 · 28 citations · 27 references

DOI

Abstract

The HLA-Cw*0701 allele and KIR haplotype AA are associated with AMD. This genotype combination suggests that natural killer cells have a role in the pathogenesis of AMD. Replication studies are needed to confirm these novel HLA-KIR associations with AMD.

References

27

A simple salting out procedure for extracting DNA from human nucleated cells

S.A. Miller, Dale D. Dykes, Herbert F. Polesky · Nucleic Acids Research · 1988 · 20.4K citations · Full text

, , +11

Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success

Susan E. Hiby, James J. Walker, Kevin M. O’Shaughnessy et al. · The Journal of Experimental Medicine · 2004 · 1.1K citations · Full text

, , +26

Phototyping: comprehensive DNA typing for HLA‐A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence‐specific primers (PCR‐SSP)

Michael Bunce, C. M. O'Neill, Martin Barnardo et al. · Tissue Antigens · 1995 · 1K citations

, , +24

Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

Robert F. Mullins, Stephen R. Russell, Don H. Anderson et al. · The FASEB Journal · 2000 · 930 citations · Full text

, , +13

Age-Specific Prevalence and Causes of Blindness and Visual Impairment in an Older Population

Caroline C. W. Klaver · Archives of Ophthalmology · 1998 · 872 citations