Concepedia

Basal α-Cell Up-Regulation in Obese Insulin-Resistant Adolescents

Ram Weiss, Ebe D’Adamo, Nicola Santoro, Karen Hershkop, Sonia Caprio

The Journal of Clinical Endocrinology & Metabolism · 2010 · 38 citations · 17 references

DOIFull text

Open access

Abstract

Islet up-regulation manifesting as basal elevated glucagon and c-peptide secretion that determines the suppressive effects of hyperinsulinemia appears early in the course of deteriorating glucose tolerance.

References

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Diabetes and obesity: the twin epidemics

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