Effects of Surface Modification on the Properties of Poly(lactide-co-glycolide) Composite Materials

Abstract

HA/PLGA composites with and without APS-modification were successfully prepared via solution dispersion method. The mechanical test of composites was performed by the three-point-bending test and the micrographs of materials were observed using SEM. The results indicate that by surface modification, uniform HA particles without agglomeration were obtained. Furthermore, the bending strengths and moduli of APS-HA/PLGA composites are higher than those of unmodified composites, which both first increased and then significantly decreased with increasing the HA content. The biocompatibility results show that modified HA/PLGA composite are more favorable biomaterials for cell adhesion, differentiation and proliferation than unmodified composites.