Concepedia

Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks

Fabio Coppedè, Enzo Grossi, Francesca Migheli, Lucia Migliore

BMC Medical Genomics · 2010 · 51 citations · 26 references

DOIFull text

Open access

Abstract

Overall, the study suggests a link between polymorphisms in folate metabolic genes and DS risk in Italian women.

References

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Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome

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Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase

Kazuhiro Yamada, Zhoutao Chen, Rima Rozen et al. · Proceedings of the National Academy of Sciences · 2001 · 409 citations · Full text

Methionine synthase (MTR) 2756 (A → G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome

Paolo Bosco, Rosa‐Maria Guéant‐Rodriguez, Guido Anello et al. · American Journal of Medical Genetics Part A · 2003 · 149 citations · Full text

Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma

Christine F. Skibola, Matthew S. Forrest, Fabio Coppedè et al. · Blood · 2004 · 147 citations · Full text