SELECTIVE CYCLOOXYGENASE-2 INHIBITORS REDUCE URETERAL CONTRACTION IN VITRO: A BETTER ALTERNATIVE FOR RENAL COLIC?

Abstract

A selective COX-2 inhibitor (NS-398) reduces ureteral contractility as effectively as indomethacin (a nonselective COX inhibitor) in both porcine and human ureteral segments in vitro (p <0.05). Selective COX-2 inhibitors may have significant clinical potential in treating renal colic as they cause less gastric ulceration.