Publication | Open Access
Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X<sub>7</sub>Receptor Antagonists/Interleukin-1β Inhibitors
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Citations
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References
2007
Year
Rat P2x7 ReceptorImmunologyPharmacotherapyChemical BiologyHuman P2x7 ReceptorMolecular PharmacologyMedicinal ChemistryNovel SeriesReceptor (Biochemistry)Pharmacological AgentDrug DevelopmentPharmacologyMolecular ModelingFunctional SelectivityNatural SciencesPhysiologyMedicineSmall MoleculesDrug Discovery
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides useful pharmacological tools for evaluation of the role of P2X7 in disease.
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