Immunotherapy with CpG DNA conjugated with T-cell epitope peptide of an allergenic Cry j 2 protein is useful for control of allergic conditions in mice

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Toll-like Receptors, Virulence Factor, Pathogenesis +7

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

Mark Roman, Elena Martín‐Orozco, Justin S. Goodman et al. · Nature Medicine · 1997 · 916 citations · Full text

Autoimmune Disease, Adaptive Immune System, T-regulatory Cell +7

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

Tim Sparwasser, Eva-Sophie Koch, R. Martin Vabulas et al. · European Journal of Immunology · 1998 · 799 citations

Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

Gunther Hartmann, Arthur Μ. Krieg · The Journal of Immunology · 2000 · 599 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

Ludwig Kappos, Giancarlo Comi, Hillel Panitch et al. · Nature Medicine · 2000 · 513 citations

Autoimmune Disease, Medicine, Immunology +12