Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

Peter Vaupel, F. Kallinowski, Paul Okunieff · PubMed · 1989 · 3.4K citations

Tumor Innervation, Biological Microenvironments, Pathology +20

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

Robert M. Sutherland · Science · 1988 · 1.8K citations

Biological Microenvironments, Abnormal Vascularization, Experimental Models +20

Generation of Solution and Surface Gradients Using Microfluidic Systems

Noo Li Jeon, Stephan K. W. Dertinger, Daniel T. Chiu et al. · Langmuir · 2000 · 947 citations

Engineering, Versatile Method, Biomedical Diagnostics +12

Generation of Gradients Having Complex Shapes Using Microfluidic Networks

Stephan K. W. Dertinger, Daniel T. Chiu, Noo Li Jeon et al. · Analytical Chemistry · 2001 · 821 citations

Microfluidic Networks, Pattern Formation, Engineering +12

Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors

Ramachandra K. Reddy, Changhui Mao, Peter Baumeister et al. · Journal of Biological Chemistry · 2003 · 688 citations · Full text

Apoptosis, Immunology, Cell Death +19