Nucleic Acids Research · 1984 · 15 citations · 18 references
Life SciencesGeneticsMolecular GeneticsGenome EvolutionGenomicsMolecular EvolutionEvolution Of Immune GenesImmunoglobulin DiversityImmunoglobulin Gene RearrangementCopy Number ChangesImmunoglobulin Gene LociImmunoglobulin Gene Locus OrganizationImmunoglobulin Gene PolymorphismImmunoglobulin Gene SegmentsImmunoglobulin Heavy Chain LocusImmunoglobulin Locus OrganizationTransposition Mechanisms
Analysis of the human VK (ref. 2) gene locus led to the detection of a new sequence family (L sequences). Its copy number is in the range of 10(2). The L sequences, which are about 500 bp long, are found as part of the 3' flanking regions of a clustered set of human VKI genes but they occur also separate from the genes. Models are discussed in which L sequences are viewed as molecular footprints of amplification and transposition processes of VK genes.
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