Synthesis, characterisation and antibacterial applications of water-soluble, silver nanoparticle-encapsulated β-cyclodextrin

Abstract

Abstract This paper describes a simple method for the synthesis of water-soluble, silver nanoparticle-encapsulated β-cyclodextrin by phase transfer of silver nanoparticles from organic to aqueous phase using β-cyclodextrin as a capping agent. β-Cyclodextrin–silver nanoparticle inclusion complex was purified, characterised by spectroscopic and microscopic analyses and tested in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, Escherichia coli and Klebsiella pneumoniae. The silver nanoparticle-encapsulated β-cyclodextrin inclusion complex displayed considerable antimicrobial activity and stability. Keywords: silver nanoparticleβ-cyclodextrinencapsulationantimicrobial activity Acknowledgement The authors thank the Department of Science and Technology (Ministry of Science and Technology), Govt. of India, New Delhi, for financial support for the major research project No. SR/S1/OC-24/2006, dated 26 October 2006.