Cyclodextrin Inclusion Compounds in Research and Industry

TLDR

Cyclodextrins are cyclic oligosaccharides derived from starch that form inclusion complexes, enabling aqueous studies of hydrophobic interactions and serving as models for polymeric starch and blue iodine‑starch. Cyclodextrins form inclusion complexes with small molecules via their 5–8 Å cavity, catalyze reactions, and are chemically modified for applications such as protecting active ingredients in pharmaceuticals, stabilizing emulsions, enhancing crop yields, and enabling gel inclusion and affinity chromatography.

Abstract

Abstract α‐, β‐, and γ‐Cyclodextrins are cyclic oligosaccharides consisting of six, seven, or eight glucose units, which can be obtained on a large scale from starch. They form inclusion compounds with smaller molecules which fit into their 5—8 Å cavity. These (crystalline) complexes are of interest for scientific research as, contrary to the classical clathrates, they exist in aqueous solution and can be used to study the hydrophobic interactions which are so important in biological systems. Cyclodextrins also serve as models both for polymeric starch and, in the form of their polyiodide complexes, for “blue iodine‐starch”. As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models. Cyclodextrins can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles—the (micro‐encapsulated) active and aromatic substances enclosed within them are protected from the effects of light and atmosphere and can be easily handled and stored in powder from. Substances which are not very soluble in water become more soluble in the presence of cyclodextrins—creams and emulsions can be stabilized, and the growth and yield of grain harvests can be increased. Cyclodextrins can be chemically modified for many different purposes; polymerized cyclodextrin or cyclodextrin bound to a polymer carrier have already been employed in gel inclusion and affinity chromatography.