Concepedia

Synthesis and Analgesic Activity of 2-Phenoxybenzoic Acid and N-Phenylanthranilic Acid Hydrazides

Ali Almasirad, Rohollah Hosseini, Hassan Jalalizadeh, Zohreh Rahimi-Moghaddam, Nazila Abaeian, Maryam Janafrooz, Mohammadreza Abbaspour, Vahid Ziaee, Afshin Dalvandi, Abbas Shafiee

Biological and Pharmaceutical Bulletin · 2006 · 31 citations · 15 references

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Abstract

A series of 2-phenoxybenzoic acid and N-phenylanthranilic acid hydrazides were synthesized and evaluated for their analgesic activities. Several compounds were significantly more potent than mefenamic acid and diclofenac sodium in abdominal constriction and formalin tests.

References

15

Formalin test in mice, a useful technique for evaluating mild analgesics

Steinar Hunskaar, Ole Bernt Fasmer, Kjell Hole · Journal of Neuroscience Methods · 1985 · 822 citations

, , +12

THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ANALGESICS

Brian A. Whittle · British Journal of Pharmacology and Chemotherapy · 1964 · 479 citations · Full text

, , +14

Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally active, nonulcerogenic antiinflammatory agents

Michael D. Mullican, Michael W. Wilson, David T. Conner et al. · Journal of Medicinal Chemistry · 1993 · 372 citations · Full text

, , +13

Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles

Ali Almasirad, Sayyed Abbas Tabatabai, Mehrdad Faizi et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 360 citations

, , +9

Leukotriene B <sub>4</sub> Produces Hyperalgesia That Is Dependent on Polymorphonuclear Leukocytes

Jon D. Levine, Wai Kit Lau, Geoffrey C. Kwiat et al. · Science · 1984 · 292 citations

, , +16