Abnormal Hepatic Methionine and Glutathione Metabolism in Patients With Alcoholic Hepatitis

Abstract

In alcoholic hepatitis, abnormal hepatic gene expression in methionine and GSH metabolism occurs and often contributes to decreased hepatic methionine, S-adenosylmethionine, cysteine, and GSH levels. It may be important to replenish these thiols in patients hospitalized with alcoholic hepatitis.