5q- Myelodysplasia Terminating in Acute Leukemia

Abstract

Brief Reports1 November 19795q- Myelodysplasia Terminating in Acute LeukemiaHANI G. JUME'AN, M.D., JOSEPH A. LIBNOCH, M.D.HANI G. JUME'AN, M.D.Search for more papers by this author, JOSEPH A. LIBNOCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-748 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently a number of reports (1-7) have described a distinctive type of refractory anemia with an abnormal number 5 chromosome in the bone marrow. We present here a case describing the second instance of the 5q- syndrome terminating in acute myeloblastic leukemia.An 83-year-old retired bricklayer was admitted in September 1975 with symptoms and signs of acute appendicitis, pallor, a left carotid bruit, and a 6-month history of macrocytic anemia unresponsive to iron, folic acid, or vitamin B12. After recovery from an appendectomy, the patient had a leukocyte count of 3100/µL with 70% neutrophils, 26% lymphocytes, 2% eosinophils, and 2%...References1. VAN DEN BERGHECASSIMANDAVIDFRYUSMICHAUXSOKAL HJGJJG. Distinct haematological disorder with deletion of long arm of No. 5 chromosome. Nature. 1974;251:437-8. CrossrefMedlineGoogle Scholar2. SOKALMICHAUXVAN DEN BERGHE GJH. A new hematologic syndrome with a distinct karyotype: the 5q- chromosome. Blood. 1975;46:519-33. CrossrefMedlineGoogle Scholar3. VERHESTVAN SCHOUBROECKWITTEKNAETSDENOLIN-REUBARS AFMJR. Specificity of the 5q- chromosome in a distinct type of refractory anemia. J Natl Cancer Inst. 1976;56:1053-4. CrossrefMedlineGoogle Scholar4. VERHESTLUSTMANWITTEKVAN SCHOUBROECKNAETS AFMFJ. Cytogenetic evidence of clonal evolution in 5q- anemia. Biomedicine [Express]. 1977;27:211-2. Letter. MedlineGoogle Scholar5. KAFFEHSUHOFFMANHIRSCHHORN SLRK. Association of 5qand refractory anemia. Am J Hematol. 1978;4:269-72. CrossrefMedlineGoogle Scholar6. KAMIHIRATOMONAGATAGAWA SYM. [An autopsy case of sideroblastic anemia associated with cytogenetic aberrations (t(2q+;5q-)) in bone marrow cells.] (Jpn.) Rinsho Ketsueki. 1977;18:1370-7. MedlineGoogle Scholar7. MAHMOODROBINSONHAMSTRAWALLNER TWRS. Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5qsyndrome, a distinct entity. Am J Med. 1979;66:946-50. CrossrefMedlineGoogle Scholar8. SULTAN A. Dysmyelopoietic syndromes, pp. 749-52. In: GRALNICK HR, moderator. Classification of acute leukemia. Ann Intern Med. 1977;87:740-53. Google Scholar9. LINMANBAGBY JG The preleukemic syndrome (hemopoietic dysplasia). Cancer. 1978;42(suppl):854-64. CrossrefMedlineGoogle Scholar10. GREENBERGMARA PB. The preleukemic syndrome: correlation of in vitro parameters of granulopoiesis with clinical features. Am J Med. 1979;66:951-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center The Medical College of Wisconsin Wood (Milwaukee), Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClonal evolution in primary 5q- syndromeLeukemic transformation in patients with the 5q− alteration: Analysis of the behavior of the 5q− clones in preleukemic to leukemic phasesDeletion of the long arm of chromosome 5 (5q−) as a secondary event in the course of refractory anemiaHematologic and cytogenetic remission of 5q- refractory anemia after syngeneic bone marrow transplantationThe 5q− anomalyChronic anemia progressing to auer rod-positive and TdT-positive acute leukemia with 5q– chromosomal anomalyCytogenetic studies in five patients with myelofibrosis and myeloid metaplasia“Atypical” Leukemias: Preleukemia, Smoldering Leukemia and Hypoplastic LeukemiaDysmyelopoietic syndromeAcquired partial deletions of the long arm of chromosome 5 in hematologic disordersThe heterogeneity of the 5q− chromosome marker in refractory anemiaThe 5q- chromosome abnormality in haematological disorders:|a collaborative study of 34 cases from the Netheralands5q- syndrome in a patient with chronic exposure to ionizing radiationThe 5q- Chromosome in Preleukaemia and Acute LeukaemiaLong arm deletion of chromosome no. 5 in a case of Philadelphia chromosome-positive chronic myelocytic leukemiaHuman PreleukemiaH. PHILLIP KOEFFLER, M.D., DAVID W. GOLDE, M.D. 1 November 1979Volume 91, Issue 5Page: 748-749KeywordsAcute myeloid leukemiaAnemiaAppendicitisBone marrowChromosomesEosinophilsFolic acidLymphocytesNeutrophilsSigns and symptoms Issue Published: 1 November 1979 PDF DownloadLoading ...