Structure and Expression of the Human Globin Genes and Murine Histoeompatability Antigen Genes

Abstract

The isolation of mammalian genes by molecular cloning and the development of the techniques of DNA-mediated transfer have made it possible to introduce genes into essentially any cell type and to study their expression at the sites of insertion. Globin genes have featured prominently in such experiments since they offer the potential for the study of those factors that govern tissue-specific gene expression and the modulation of gene expression during development; in addition, the globin system permits study of the general features of gene expression, such as the promotion of RNA synthesis.