Noradrenaline is necessary for the hedonic properties of addictive drugs

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

Richard B. Rothman, Michael H. Baumann, Christina M. Dersch et al. · Synapse · 2000 · 927 citations · Full text

Neuropsychology, Da Release, Psychopharmacology +17

Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine

Ronald Kuczenski, David S. Segal · Journal of Neurochemistry · 1997 · 625 citations

Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis

Luis Hernandez, Bartley G. Hoebel · Life Sciences · 1988 · 619 citations

Behavioral Sciences, Behavioral Neuroscience, Addiction +10

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

Ichiro Sora, Christine H. Wichems, Nobuyuki Takahashi et al. · Proceedings of the National Academy of Sciences · 1998 · 509 citations · Full text

Serotonin-transporter Knockout Mice, Behavioral Addiction, Neurotransmitter +20