Regulation of extracellular signal‐regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine

Abstract

The activation of ERK expression by nicotine suggests a potential role for nicotine in the pathogenesis of cigarette smoking-associated periodontal disease. In addition, nicotine-induced ERK expression was down-regulated by NS-398, dexamethasone, OTZ, herbimycin A, and curcumin.