Spectrophotometric Determination of Metformin via Charge-Transfer Complex with Iodine

Abstract

Abstract A spectroscopic method is described for the determination of Metformin based on its formation of molecular complex with iodine in dichloroethane. Quantitative measurements are made at the maximum absorption of 295nm. The molar ratio of the formed metformin-iodine complex is 1:1 as revealed by Job's method. Beers' law is obeyed in the range 2–12 ug.ml−1 base solution. The proposed method is statistically comparable with the official B. P. method. When applied to pharmaceutical preparation, tablets, average percentage recovery of 99.97 ± 0.81 was obtained.