Griseofulvin-Warfarin Antagonism

Abstract

THE DEMONSTRATION that the metabolism of one drug can alter the metabolism of another has occasioned considerable interest.¹Recent experimental work has shown that an increase within cells of the liver of smooth-surfaced endoplasmic reticulum parallels an increase of this altered metabolism.²Of further interest is the fact that the same or similar loci seem to be implicated in cholesterol synthesis.³Because it has been reported that the metabolism of both griseofulvin and coumarin congeners are increased by treatment with phenobarbital, presumably via enzyme induction,^4,5it seemed within reason that one of these might act as an inducer to accelerate metabolism of the other. It should be noted, however, that the fact that a drug either acts as an inducer or is subject to altered metabolism via enzyme induction does not necessarily indicate that it will function in both capacities. <h3>Report of Cases</h3><h3>Case 1.—</h3> A