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Inhibition of DNA Repair Replication by DNA Binding Drugs Which Sensitize Cells to Alkylating Agents and X-Rays
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1972
Year
ChromatinGenome InstabilityUv-stimulated IncorporationDna DamageNormal Human LymphocytesMedicineNatural SciencesPhotocarcinogenesisMolecular BiologyDna ReplicationRadiopharmaceutical TherapyDna Repair ReplicationPharmacologyCell BiologyTritiated ThymidineAlkylating AgentsMutagenesis
A number of DNA binding drugs which sensitize living cells to the action of alkylating agents and X-rays have been shown to inhibit the uv-stimulated incorporation of tritiated thymidine by normal human lymphocytes incubated in the presence of hydroxyurea.