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Coupling of a Nucleoside with DNA by a Methyltransferase
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1998
Year
Bioorganic ChemistryMtase-catalyzed ReactionDna MethylationMolecular BiologyChemical BiologyEpigeneticsAcceptors RBiosynthesisDna ComputingBiochemistryBiocatalysisOligonucleotideDna ReplicationProtein BiosynthesisChromatinNatural SciencesEnzyme CatalysisSynthetic BiologyMedicineActivated Methyl Group
How to outwit a methyltransferase: Methyltransferases (Mtases) catalyze the transfer of the activated methyl group from the cofactor S-adenosyl-L-methionine (1) to acceptors R within a large variety of biomolecules. Through the use of the cofactor analogue 2 a whole nucleoside was coupled to DNA in a Mtase-catalyzed reaction.