Inhibition of cyclic 3′,5′-nucleotide phosphodiesterase—a possible mechanism of action of bifunctional alkylating agents

A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter

George A. Bray · Analytical Biochemistry · 1960 · 7.5K citations

Engineering, Chemistry, Analytical Chemistry +12

The reaction of mono- and di-functional alkylating agents with nucleic acids

P. Brookes, PD LAWLEY · Biochemical Journal · 1961 · 584 citations · Full text

Pharmacy, Biochemistry, Molecular Biology +11

Cyclic AMP levels in fibroblasts: Relationship to growth rate and contact inhibition of growth

J Otten, George S. Johnson, Ira Pastan · Biochemical and Biophysical Research Communications · 1971 · 436 citations

Life Sciences, Biochemistry, Cell Biology +12

Molecular Mechanism of the Cytotoxic Action of Difunctional Alkylating Agents and of Resistance to this Action

P.D. Lawley, P. Brookes · Nature · 1965 · 255 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Cyclic Nucleotides as Intracellular Mediators of the Expression of Antigen-sensitive Cells

James D. Watson, Ruth Epstein, Melvin Cohn · Nature · 1973 · 159 citations

Life Sciences, Cell Biology, Immunology +16